Denali Therapeutics Inc. (DNLI) intrinsic value & 10-year financials

Denali Therapeutics Inc. (DNLI) has a Graham intrinsic value of $20.93 per share. At $17.61 on Oct 17, 2026, the stock trades 16% below that value. Over the last 10 fiscal years revenue grew 20.7% a year to $0, with an average return on invested capital of -22.0%.

Graham intrinsic value
$20.93
Share price (Oct 17, 2026)
$17.61
Price vs Graham value
16% below
Market cap
$3.0B
Revenue (FY2025)
$0
Revenue growth (10-yr CAGR)
20.7%
ROIC (10-yr avg)
-22.0%
Free cash flow (FY2025)
-$422.1M

DNLI 10-year financial history

Fiscal year Revenue Net income EPS (diluted) Free cash flow Operating margin ROIC
FY2025 $0 -$512.5M -$2.97 -$422.1M — -57.3%
FY2024 $0 -$422.8M -$2.57 -$363.6M — -47.6%
FY2023 $330.5M -$145.2M -$1.06 -$370.9M -59.5% -21.5%
FY2022 $105.1M -$326.0M -$2.60 -$262.5M -324.3% -42.5%
FY2021 $48.7M -$290.6M -$2.39 -$219.9M -607.8% -41.1%
FY2020 $335.6M $71.1M $0.63 $413.1M 18.7% 11.5%
FY2019 $26.7M -$197.6M -$2.07 -$169.5M -799.1% -55.4%
FY2018 $129.2M -$36.2M -$0.39 $46.7M -35.9% -9.2%
FY2017 $0 -$88.2M — -$79.5M — -48.5%
FY2016 $0 -$86.7M — -$78.0M — 92.0%

Source: annual 10-K filings on SEC EDGAR. Figures in USD.

Executive summary

Denali Therapeutics Inc. revenue growth over the past decade is N/A; insufficient history prevents a reliable 10-year CAGR calculation.

Denali Therapeutics Inc. has historically struggled to out-earn its cost of capital, averaging just -36.3% ROIC.

Denali Therapeutics Inc. capital allocation metrics are N/A for the decade; share count and net debt history are incomplete.

Benjamin Graham lens

Under Benjamin Graham's formula using SEC EDGAR fundamentals, Denali Therapeutics Inc. is modeled at 15.0% normalized earnings growth with a 5.1% bond-yield adjustment. The resulting Graham intrinsic value estimate is $20.93 per share.

DNLI stock: frequently asked questions

What is the intrinsic value of Denali Therapeutics Inc. (DNLI) stock?

Using Benjamin Graham's revised formula, V = EPS × (8.5 + 2g) × 4.4 / Y, with reported diluted earnings per share, a 15.0% normalized growth rate (capped at 15%) and a 5.1% AAA corporate bond yield, DNLI's intrinsic value is about $20.93 per share.

Is DNLI stock undervalued?

At $17.61 (close on Oct 17, 2026), DNLI trades 16% below its Graham value of $20.93. On Graham's terms that leaves a margin of safety. A formula is a starting point for research, not a recommendation.

How fast has Denali Therapeutics Inc. grown?

Revenue went from $0 in fiscal 2016 to $0 in fiscal 2025, a compound annual growth rate of 20.7%. Net income was -$512.5M in fiscal 2025.

Does Denali Therapeutics Inc. generate free cash flow?

Denali Therapeutics Inc. generated -$422.1M of free cash flow (operating cash flow minus capital expenditures) in fiscal 2025. Free cash flow was positive in 2 of the last 10 reported years.

What is DNLI's return on invested capital?

Average ROIC over the last 10 fiscal years was -22.0%, and average return on equity was -15.2%. Sustained ROIC above about 15% usually points to a durable competitive advantage.

Where does this DNLI data come from?

From Denali Therapeutics Inc.'s annual 10-K filings on SEC EDGAR, most recently filed Aug 6, 2026. Prices are end-of-day snapshots; valuations are formula outputs, not investment advice.

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