Karyopharm Therapeutics Inc. (KPTI) intrinsic value & 10-year financials

Karyopharm Therapeutics Inc. (KPTI) has no Graham intrinsic value right now because the formula needs positive earnings. Over the last 10 fiscal years revenue grew 114.2% a year to $146.1M, with an average return on invested capital of 160.5%.

Graham intrinsic value
—
Share price (Oct 17, 2026)
$0.39
Market cap
$4.3K
Revenue (FY2025)
$146.1M
Revenue growth (10-yr CAGR)
114.2%
ROIC (10-yr avg)
160.5%
Free cash flow (FY2025)
—

KPTI 10-year financial history

Fiscal year Revenue Net income EPS (diluted) Free cash flow Operating margin ROIC
FY2025 $146.1M -$196.0M -$17.93 — -62.1% 30.8%
FY2024 $145.2M -$76.4M -$0.93 -$127.6M -82.2% 55.9%
FY2023 $146.0M -$143.1M -$1.25 — -88.7% 78.2%
FY2022 $157.1M -$165.3M -$2.02 -$149.7M -90.5% 119.7%
FY2021 $209.8M -$124.1M -$1.65 -$107.3M -46.8% 169.5%
FY2020 $108.1M -$196.3M -$2.72 -$160.4M -159.0% 382.0%
FY2019 $40.9M -$199.6M — -$191.0M -462.9% 287.3%
FY2018 $30.3M -$178.4M — -$161.5M -593.0% —
FY2017 $1.6M -$129.0M — -$73.8M -8133.2% —
FY2016 $154.0K -$109.6M — -$84.5M -71903.9% —

Source: annual 10-K filings on SEC EDGAR. Figures in USD.

Executive summary

Karyopharm Therapeutics Inc. is a consistent compounder, expanding top-line revenue at 114.2% annually over the past decade.

Karyopharm Therapeutics Inc. has earned high returns on invested capital, averaging 41.8% ROIC over the available history. High ROIC is consistent with a durable franchise, but it is not by itself proof of an economic moat.

Karyopharm Therapeutics Inc. capital allocation metrics are N/A for the decade; share count and net debt history are incomplete.

Benjamin Graham lens

Under Benjamin Graham's formula using SEC EDGAR fundamentals, Karyopharm Therapeutics Inc. is modeled at 15.0% normalized earnings growth with a 5.1% bond-yield adjustment. The resulting Graham intrinsic value estimate is $-595.56 per share.

KPTI stock: frequently asked questions

What is the intrinsic value of Karyopharm Therapeutics Inc. (KPTI) stock?

Graham's formula only works with positive earnings. Karyopharm Therapeutics Inc. reported diluted EPS of -$17.93 in fiscal 2025, so no Graham value is shown. The 10-year table shows revenue and cash-flow trends instead.

How fast has Karyopharm Therapeutics Inc. grown?

Revenue went from $154.0K in fiscal 2016 to $146.1M in fiscal 2025, a compound annual growth rate of 114.2%. Net income was -$196.0M in fiscal 2025.

What is KPTI's return on invested capital?

Average ROIC over the last 10 fiscal years was 160.5%, and average return on equity was 67.9%. Sustained ROIC above about 15% usually points to a durable competitive advantage.

Where does this KPTI data come from?

From Karyopharm Therapeutics Inc.'s annual 10-K filings on SEC EDGAR, most recently filed Aug 13, 2026. Prices are end-of-day snapshots; valuations are formula outputs, not investment advice.

Similar pharmaceutical preparations stocks