Pharmaceutical Preparations stocks: intrinsic value, ROIC & growth
454 U.S. pharmaceutical preparations companies with at least three years of SEC filings, ranked by size. 118 of the 157 with a current price trade below their Graham intrinsic value. The median company earned a -25.8% average return on invested capital and grew revenue 11.9% a year.
Updated October 18, 2026
454companies
118below Graham value
-25.8%median 10-yr ROIC
11.9%median revenue CAGR
Most undervalued pharmaceutical preparations stocks
| Ticker | Company | Upside | Price | Graham value | Price vs value | Market cap | ROIC (10y) | Revenue CAGR |
|---|---|---|---|---|---|---|---|---|
| AMPH | Amphastar Pharmaceuticals, Inc. | +161% | $25.87 | $67.43 | 62% below | $1.2B | 8.3% | 12.2% |
| ZTS | Zoetis | +152% | $79.38 | $199.96 | 60% below | $35.2B | 22.9% | 7.6% |
| HRMY | Harmony Biosciences Holdings, Inc. | +137% | $37.95 | $90.01 | 58% below | $2.2B | 45.8% | 129.2% |
| GSK | GSK PLC | +86% | £49.51 | £92.21 | 46% below | £100.3B | 19.8% | 1.8% |
| REGN | Regeneron Pharmaceuticals | +74% | $790.74 | $1,377.79 | 43% below | $85.9B | 23.2% | 12.8% |
| TGTX | TG THERAPEUTICS, INC. | +70% | $53.97 | $92.01 | 41% below | $8.7B | 161.3% | 151.7% |
| MRK | Merck & Co. | +66% | $145.95 | $241.81 | 40% below | $365.9B | 15.8% | 5.6% |
| PBH | Prestige Consumer Healthcare Inc. | +66% | $49.92 | $82.65 | 40% below | $2.4B | 6.5% | 2.4% |
| ANIP | ANI PHARMACEUTICALS INC | +53% | $72.29 | $110.28 | 34% below | $1.5B | 4.2% | 23.9% |
| ABT | Abbott Laboratories | +18% | $104.89 | $123.56 | 15% below | $183.3B | 10.8% | 8.7% |
Highest-ROIC pharmaceutical preparations stocks
| Ticker | Company | 10-yr ROIC | Price | Graham value | Price vs value | Market cap | ROIC (10y) | Revenue CAGR |
|---|---|---|---|---|---|---|---|---|
| GOSS | Gossamer Bio, Inc. | 193.7% | $8.77 | $69.22 | 87% below | $2.0B | 193.7% | -57.7% |
| NGNE | Neurogene Inc. | 181.7% | $23.25 | $278.16 | 92% below | $495.8M | 181.7% | -42.3% |
| BBIO | BridgeBio Pharma, Inc. | 178.0% | $66.39 | — | — | $12.7B | 178.0% | 52.1% |
| TGTX | TG THERAPEUTICS, INC. | 161.3% | $53.97 | $92.01 | 41% below | $8.7B | 161.3% | 151.7% |
| AMRN | AMARIN CORP PLCUK | 140.7% | $11.32 | $0.34 | 3229% above | $4.7B | 140.7% | 5.7% |
| AUPH | Aurinia Pharmaceuticals Inc. | 113.0% | $16.51 | $68.76 | 76% below | $2.3B | 113.0% | 150.1% |
| WVE | Wave Life Sciences Ltd. | 112.2% | $3.13 | — | — | $527.9M | 112.2% | 50.3% |
| PVLA | PALVELLA THERAPEUTICS, INC. | 97.2% | $120.30 | $14.42 | 734% above | $1.4B | 97.2% | 31.1% |
| VSTM | Verastem, Inc. | 89.1% | $8.65 | — | — | $599.5M | 89.1% | 2.1% |
| AQST | Aquestive Therapeutics, Inc. | 83.8% | $3.78 | $0.96 | 294% above | $404.2M | 83.8% | -5.0% |
All pharmaceutical preparations stocks (largest 250 of 454)
| Ticker | Company | Price | Graham value | Price vs value | Market cap | ROIC (10y) | Revenue CAGR |
|---|---|---|---|---|---|---|---|
| LLY | Lilly (Eli) | $1,257.03 | $762.30 | 65% above | $1.1T | 26.5% | 13.3% |
| BCAX | Bicara Therapeutics Inc. | $16.78 | — | — | $917.5B | -15.6% | — |
| JNJ | Johnson & Johnson | $255.56 | $233.14 | 10% above | $620.9B | 22.0% | 2.7% |
| AKTX | Akari Therapeutics Plc | $8.18 | — | — | $550.7B | -418.8% | — |
| ONC | BeOne Medicines Ltd. | $369.06 | $6.31 | 5749% above | $544.3B | -64.4% | 157.6% |
| ABBV | AbbVie | $285.42 | — | — | $506.0B | 25.9% | 10.1% |
| MRK | Merck & Co. | $145.95 | $241.81 | 40% below | $365.9B | 15.8% | 5.6% |
| AZN | ASTRAZENECA PLC | $165.41 | $161.48 | 2% above | $256.4B | 11.3% | 11.0% |
| ABT | Abbott Laboratories | $104.89 | $123.56 | 15% below | $183.3B | 10.8% | 8.7% |
| PFE | Pfizer | $29.58 | $13.94 | 112% above | $169.0B | 12.3% | 1.9% |
| VRTX | Vertex Pharmaceuticals | $499.74 | $508.86 | 2% below | $128.9B | 34.3% | 24.2% |
| BMY | Bristol Myers Squibb | $59.75 | $43.34 | 38% above | $121.8B | 9.2% | 10.6% |
| GSK | GSK PLC | £49.51 | £92.21 | 46% below | £100.3B | 19.8% | 1.8% |
| REGN | Regeneron Pharmaceuticals | $790.74 | $1,377.79 | 43% below | $85.9B | 23.2% | 12.8% |
| TEVA | TEVA PHARMACEUTICAL INDUSTRIES LTD | $41.50 | $40.19 | 3% above | $48.3B | -2.7% | -2.6% |
| ZTS | Zoetis | $79.38 | $199.96 | 60% below | $35.2B | 22.9% | 7.6% |
| TEVJF | TEVA PHARMACEUTICAL INDUSTRIES LTD | — | $40.19 | — | — | -2.7% | -2.6% |
| RPRX | Royalty Pharma plc | $60.96 | $31.97 | 91% above | $34.4B | 10.2% | 4.1% |
| ALNY | ALNYLAM PHARMACEUTICALS, INC. | $231.83 | $77.39 | 200% above | $31.2B | 373.6% | 62.4% |
| UTHR | UNITED THERAPEUTICS Corp | $533.12 | $536.97 | 1% below | $25.5B | 18.5% | 8.0% |
| ZLAB | Zai Lab Ltd | $23.19 | — | — | $25.4B | -180.0% | 221.3% |
| LGVN | Longeveron Inc. | $1.39 | — | — | $24.4B | -360.5% | 85.2% |
| ROIV | Roivant Sciences Ltd. | $33.53 | — | — | $23.3B | 94.0% | -19.1% |
| VTRS | Viatris Inc | $18.66 | $0.66 | 2727% above | $22.3B | 0.6% | 3.4% |
| INSM | INSMED Inc | $96.27 | — | — | $19.2B | -310.9% | 80.2% |
| CORT | CORCEPT THERAPEUTICS INC | $110.16 | $27.24 | 304% above | $13.2B | 51.0% | 28.2% |
| JAZZ | Jazz Pharmaceuticals plc | $210.23 | $248.81 | 16% below | $12.8B | 7.5% | 12.4% |
| BBIO | BridgeBio Pharma, Inc. | $66.39 | — | — | $12.7B | 178.0% | 52.1% |
| ELAN | Elanco Animal Health Inc | $23.55 | $11.43 | 106% above | $11.7B | -2.1% | 5.5% |
| SMMT | Summit Therapeutics Inc. | £14.63 | — | — | £10.9B | -206.2% | -21.1% |
| BMRN | BIOMARIN PHARMACEUTICAL INC | $54.68 | — | — | $10.8B | -0.8% | 12.5% |
| MDGL | MADRIGAL PHARMACEUTICALS, INC. | $449.74 | — | — | $10.1B | -148.1% | 432.1% |
| TGTX | TG THERAPEUTICS, INC. | $53.97 | $92.01 | 41% below | $8.7B | 161.3% | 151.7% |
| PTGX | Protagonist Therapeutics, Inc | $128.75 | $89.41 | 44% above | $8.2B | -56.6% | 10.9% |
| AXSM | Axsome Therapeutics, Inc. | $157.14 | — | — | $7.8B | 1247.3% | 71.3% |
| ARWR | ARROWHEAD PHARMACEUTICALS, INC. | $55.90 | $22.92 | 144% above | $7.5B | -117.6% | 159.0% |
| ALKS | Alkermes plc. | $41.22 | $29.93 | 38% above | $7.0B | 0.9% | 7.9% |
| IONS | IONIS PHARMACEUTICALS INC | $42.94 | $43.97 | 2% below | $6.9B | -17.0% | 10.9% |
| VREOF | Vireo Growth Inc. | $9.00 | — | — | $6.6B | -4.0% | 40.4% |
| AMRX | Amneal Pharmaceuticals, Inc. | $19.18 | — | — | $6.2B | 4.3% | 12.8% |
| KNSA | Kiniksa Pharmaceuticals International, plc | $78.59 | — | — | $6.2B | -32.4% | 104.8% |
| LGND | LIGAND PHARMACEUTICALS INC | $295.54 | $203.61 | 45% above | $6.0B | 16.4% | 10.5% |
| RYTM | RHYTHM PHARMACEUTICALS, INC. | $86.17 | — | — | $5.6B | -109.4% | 178.5% |
| PRAX | Praxis Precision Medicines, Inc. | $241.76 | — | — | $5.4B | -633.7% | 249.5% |
| PTCT | PTC THERAPEUTICS, INC. | $59.24 | $258.42 | 77% below | $5.2B | -53.1% | 40.2% |
| AMRN | AMARIN CORP PLCUK | $11.32 | $0.34 | 3229% above | $4.7B | 140.7% | 5.7% |
| TVTX | Travere Therapeutics, Inc. | $49.60 | — | — | $4.4B | -233.1% | 15.6% |
| INDV | Indivior Pharmaceuticals, Inc. | $32.45 | $23.06 | 41% above | $4.2B | -34.4% | 11.9% |
| MIRM | Mirum Pharmaceuticals, Inc. | $80.14 | — | — | $4.0B | -43.9% | 128.4% |
| EWTX | Edgewise Therapeutics, Inc. | $37.19 | — | — | $3.8B | -20.2% | — |
| COGT | Cogent Biosciences, Inc. | $29.52 | — | — | $3.8B | 636.7% | -2.0% |
| ERAS | Erasca, Inc. | $13.39 | — | — | $3.8B | 22.8% | — |
| GPCR | Structure Therapeutics Inc. | $21.08 | — | — | $3.7B | -7.2% | — |
| ARQT | Arcutis Biotherapeutics, Inc. | $28.82 | — | — | $3.7B | -62.1% | 365.6% |
| OGN | Organon & Co. | $13.76 | — | — | $3.6B | 21.0% | -3.7% |
| ABCL | AbCellera Biologics Inc. | $11.80 | $16.61 | 29% below | $3.5B | 2.7% | 36.5% |
| ACAD | ACADIA PHARMACEUTICALS INC | $19.12 | $76.40 | 75% below | $3.2B | -35.1% | 58.1% |
| LQDA | Liquidia Corp | $34.35 | — | — | $3.0B | -307.1% | 64.2% |
| IDYA | IDEAYA Biosciences, Inc. | $32.85 | — | — | $2.9B | -1.8% | 62.1% |
| VKTX | Viking Therapeutics, Inc. | $25.17 | — | — | $2.8B | -62.1% | — |
| DNTH | Dianthus Therapeutics, Inc. /DE/ | $72.09 | $78.78 | 8% below | $2.8B | -56.1% | -15.1% |
| XENE | Xenon Pharmaceuticals Inc. | $33.49 | — | — | $2.7B | -56.9% | 17.2% |
| TNGX | Tango Therapeutics, Inc. | $22.04 | — | — | $2.6B | -211.1% | 52.1% |
| AMLX | Amylyx Pharmaceuticals, Inc. | $26.34 | $23.25 | 13% above | $2.5B | -67.0% | 574.3% |
| PBH | Prestige Consumer Healthcare Inc. | $49.92 | $82.65 | 40% below | $2.4B | 6.5% | 2.4% |
| RCUS | Arcus Biosciences, Inc. | $22.12 | $23.58 | 6% below | $2.4B | -46.2% | 48.3% |
| BHC | Bausch Health Companies Inc. | $6.30 | — | — | $2.4B | 0.8% | 0.7% |
| NAMS | NewAmsterdam Pharma Co N.V. | $19.83 | $105.24 | 81% below | $2.3B | 324.0% | -39.7% |
| PRGO | PERRIGO Co plc | $16.63 | $3.45 | 382% above | $2.3B | -1.7% | -2.4% |
| AUPH | Aurinia Pharmaceuticals Inc. | $16.51 | $68.76 | 76% below | $2.3B | 113.0% | 150.1% |
| HRMY | Harmony Biosciences Holdings, Inc. | $37.95 | $90.01 | 58% below | $2.2B | 45.8% | 129.2% |
| SUPN | SUPERNUS PHARMACEUTICALS, INC. | $37.88 | $42.36 | 11% below | $2.1B | 15.6% | 14.3% |
| NRIX | Nurix Therapeutics, Inc. | $24.42 | — | — | $2.1B | -46.2% | 18.0% |
| IRON | Disc Medicine, Inc. | $56.84 | — | — | $2.0B | -17.1% | — |
| GOSS | Gossamer Bio, Inc. | $8.77 | $69.22 | 87% below | $2.0B | 193.7% | -57.7% |
| PGEN | PRECIGEN, INC. | $6.39 | — | — | $2.0B | -84.4% | -28.2% |
| RTEZ | REST EZ Inc. | $70.00 | — | — | $1.9B | -141.2% | -63.8% |
| ZYME | Zymeworks Inc. | $25.03 | $63.11 | 60% below | $1.9B | -58.3% | 22.2% |
| DYN | Dyne Therapeutics, Inc. | $14.25 | — | — | $1.8B | -248.0% | — |
| MBX | MBX Biosciences, Inc. | $49.61 | — | — | $1.8B | -44.8% | — |
| VERA | Vera Therapeutics, Inc. | $27.88 | — | — | $1.8B | -80.3% | — |
| XERS | Xeris Biopharma Holdings, Inc. | $10.31 | — | — | $1.8B | -53.5% | 70.7% |
| INVA | Innoviva, Inc. | $20.78 | $109.61 | 81% below | $1.8B | 40.2% | 13.3% |
| SRPT | Sarepta Therapeutics, Inc. | $17.10 | $77.72 | 78% below | $1.7B | -35.7% | 91.3% |
| XNCR | Xencor Inc | $22.85 | $13.78 | 66% above | $1.7B | -11.4% | 1.6% |
| SDGR | Schrodinger, Inc. | $22.60 | $17.94 | 26% above | $1.7B | -27.9% | 20.0% |
| PCRX | Pacira BioSciences, Inc. | $36.34 | — | — | $1.6B | 3.2% | 11.6% |
| SEPN | Septerna, Inc. | $36.35 | $9.63 | 277% above | $1.6B | -68.5% | 1644.5% |
| TRVI | Trevi Therapeutics, Inc. | $11.88 | — | — | $1.6B | 37.7% | — |
| CUE | Cue Biopharma, Inc. | $16.71 | — | — | $1.6B | 230.8% | 57.5% |
| PAHC | PHIBRO ANIMAL HEALTH CORP | $38.82 | $25.15 | 54% above | $1.6B | 15.2% | 6.2% |
| ANIP | ANI PHARMACEUTICALS INC | $72.29 | $110.28 | 34% below | $1.5B | 4.2% | 23.9% |
| IMNM | Immunome Inc. | $16.47 | $106.42 | 85% below | $1.4B | -707.0% | -29.6% |
| RARE | Ultragenyx Pharmaceutical Inc. | $14.54 | — | — | $1.4B | -149.9% | 158.0% |
| STOK | Stoke Therapeutics, Inc. | $24.17 | — | — | $1.4B | 430.8% | 145.9% |
| MLYS | Mineralys Therapeutics, Inc. | $20.30 | — | — | $1.4B | -22.4% | — |
| PVLA | PALVELLA THERAPEUTICS, INC. | $120.30 | $14.42 | 734% above | $1.4B | 97.2% | 31.1% |
| ANAB | ANAPTYSBIO, INC | $46.61 | — | — | $1.3B | -170.3% | 34.1% |
| OCUL | OCULAR THERAPEUTIX, INC | $6.87 | — | — | $1.3B | 66.8% | 44.5% |
| QURE | uniQure N.V. | $21.78 | — | — | $1.3B | 861.9% | -4.8% |
| AMPH | Amphastar Pharmaceuticals, Inc. | $25.87 | $67.43 | 62% below | $1.2B | 8.3% | 12.2% |
| SLN | Silence Therapeutics plc | £8.68 | — | — | £1.2B | 75.0% | 14.8% |
| CPRX | CATALYST PHARMACEUTICALS, INC. | — | $55.80 | — | — | -171.8% | 174.6% |
| BHVN | Biohaven Ltd. | $10.78 | — | — | $1.2B | -276.7% | — |
| OPK | OPKO HEALTH, INC. | $1.53 | — | — | $1.1B | -8.1% | -6.6% |
| SNDX | Syndax Pharmaceuticals Inc | $12.90 | $15.28 | 16% below | $1.1B | -155.0% | 73.3% |
| ZBIO | Zenas BioPharma, Inc. | $24.84 | $743.16 | 97% below | $1.1B | -83.5% | -55.3% |
| TYRA | Tyra Biosciences, Inc. | $18.52 | — | — | $1.1B | -202.5% | — |
| SLS | SELLAS Life Sciences Group, Inc. | $9.98 | $10.01 | 0% below | $1.1B | 630.0% | -27.4% |
| IMUX | IMMUNIC, INC. | $6.97 | — | — | $1.1B | 380.4% | — |
| ORIC | Oric Pharmaceuticals, Inc. | $12.35 | — | — | $1.1B | -47.0% | — |
| RAPP | Rapport Therapeutics, Inc. | $27.57 | — | — | $1.1B | -35.0% | — |
| ORKA | Oruka Therapeutics, Inc. | $71.93 | — | — | $1.0B | 440.7% | — |
| JANX | Janux Therapeutics, Inc. | $16.51 | — | — | $1.0B | -12.5% | 28.8% |
| CMPS | COMPASS Pathways plc | $10.75 | — | — | $1.0B | -260.8% | — |
| HROW | HARROW, INC. | $27.28 | $0.33 | 8167% above | $1.0B | -18.8% | 33.7% |
| SVRA | Savara Inc | $4.45 | — | — | $989.6M | -93.4% | 19.0% |
| MRVI | MARAVAI LIFESCIENCES HOLDINGS, INC. | $6.79 | $25.04 | 73% below | $980.2M | 21.4% | 4.4% |
| MNKD | MANNKIND CORP | $3.04 | — | — | $954.9M | 8.5% | 8.0% |
| COLL | COLLEGIUM PHARMACEUTICAL, INC | $23.19 | $57.46 | 60% below | $920.7M | -82.5% | 97.5% |
| RIGL | RIGEL PHARMACEUTICALS INC | $45.97 | $647.04 | 93% below | $866.1M | -281.2% | 34.5% |
| VRDN | Viridian Therapeutics, Inc.DE | $19.03 | — | — | $851.7M | 833.0% | 40.4% |
| CYRX | Cryoport, Inc. | $16.84 | $46.50 | 64% below | $843.2M | -630.1% | 45.9% |
| ABUS | Arbutus Biopharma Corp | $4.22 | — | — | $808.6M | -99.2% | 28.3% |
| ESPR | Esperion Therapeutics, Inc. | — | — | — | — | -0.3% | 18.1% |
| KURA | Kura Oncology, Inc. | $9.08 | — | — | $796.1M | -65.7% | 25.2% |
| GERN | GERON CORP | $1.17 | $7.39 | 84% below | $780.0M | -55.1% | -37.2% |
| CBIO | CRESCENT BIOPHARMA, INC. | $11.84 | — | — | $763.4M | 699.8% | 103.0% |
| CRVS | Corvus Pharmaceuticals, Inc. | $9.52 | — | — | $759.2M | -70.4% | — |
| ARDX | ARDELYX, INC. | $3.09 | — | — | $744.8M | -81.9% | 32.8% |
| CLYM | Climb Bio, Inc. | $9.82 | — | — | $665.9M | -31.5% | — |
| AVBP | ArriVent BioPharma, Inc. | $16.66 | — | — | $640.8M | 22.1% | — |
| ANRO | Alto Neuroscience, Inc. | $21.94 | — | — | $633.0M | 694.4% | — |
| GYRE | GYRE THERAPEUTICS, INC. | $6.08 | $0.66 | 821% above | $627.3M | 11.0% | 87.9% |
| MLTX | MoonLake Immunotherapeutics | $9.55 | — | — | $615.6M | -259.3% | — |
| NKTR | NEKTAR THERAPEUTICS | $35.78 | — | — | $603.6M | -47.2% | -11.5% |
| VSTM | Verastem, Inc. | $8.65 | — | — | $599.5M | 89.1% | 2.1% |
| DSGN | Design Therapeutics, Inc. | $10.31 | — | — | $591.1M | -8.4% | — |
| OLMA | Olema Pharmaceuticals, Inc. | $6.58 | — | — | $572.5M | -30.4% | — |
| IRWD | IRONWOOD PHARMACEUTICALS INC | $3.50 | $1.40 | 150% above | $570.4M | -64.8% | 0.9% |
| ZVRA | ZEVRA THERAPEUTICS, INC. | $9.94 | $44.84 | 78% below | $569.2M | -484.8% | 42.3% |
| LXRX | LEXICON PHARMACEUTICALS, INC. | $1.52 | $38.53 | 96% below | $551.8M | -82.3% | 15.3% |
| SYRE | Spyre Therapeutics, Inc. | $79.90 | $651.93 | 88% below | $551.1M | 13.3% | -21.0% |
| ANNX | Annexon, Inc. | $3.41 | — | — | $528.9M | -79.6% | — |
| WVE | Wave Life Sciences Ltd. | $3.13 | — | — | $527.9M | 112.2% | 50.3% |
| ALMS | ALUMIS INC. | $6.12 | — | — | $520.4M | 19.9% | — |
| PHAT | Phathom Pharmaceuticals, Inc. | $6.92 | — | — | $504.6M | 17.7% | 1502.4% |
| PBYI | PUMA BIOTECHNOLOGY, INC. | $9.83 | $20.26 | 51% below | $497.9M | -175.2% | 30.2% |
| NGNE | Neurogene Inc. | $23.25 | $278.16 | 92% below | $495.8M | 181.7% | -42.3% |
| ARVN | ARVINAS, INC. | $6.97 | — | — | $494.2M | -64.2% | 55.8% |
| EOLS | Evolus, Inc. | $7.10 | — | — | $457.7M | -95.5% | 42.9% |
| PRTA | PROTHENA CORP PUBLIC LTD CO | $8.35 | $45.84 | 82% below | $449.5M | -2193.0% | 27.9% |
| NIKA | NIKA PHARMACEUTICALS, INC | $0.41 | — | — | $429.5M | 2371.7% | — |
| JBIO | Jade Biosciences, Inc. | $13.47 | — | — | $422.4M | -39.0% | — |
| NVCT | Nuvectis Pharma, Inc. | $18.60 | — | — | $405.7M | -296.9% | — |
| AQST | Aquestive Therapeutics, Inc. | $3.78 | $0.96 | 294% above | $404.2M | 83.8% | -5.0% |
| KROS | Keros Therapeutics, Inc. | $10.66 | $76.40 | 86% below | $403.6M | -546.5% | 70.3% |
| ACRS | Aclaris Therapeutics, Inc. | $3.28 | — | — | $402.0M | -80.3% | 21.2% |
| SPRY | ARS Pharmaceuticals, Inc. | $4.02 | $2.66 | 51% above | $396.2M | 318.7% | 97.8% |
| STTK | Shattuck Labs, Inc. | $5.42 | $33.20 | 84% below | $377.2M | -93.8% | -31.7% |
| EBS | Emergent BioSolutions Inc. | $6.38 | $3.39 | 88% above | $361.7M | 1.5% | 4.8% |
| AVIR | Atea Pharmaceuticals, Inc. | $4.32 | $45.51 | 91% below | $352.1M | -44.4% | 622.5% |
| CTMX | CytomX Therapeutics, Inc. | $2.28 | $12.49 | 82% below | $314.5M | -9.4% | 21.9% |
| CAPR | CAPRICOR THERAPEUTICS, INC. | $6.71 | $0.75 | 795% above | $311.9M | 44.7% | 23.9% |
| LBRX | LB PHARMACEUTICALS INC | $36.74 | — | — | $295.6M | 69.4% | — |
| BNTC | Benitec Biopharma Inc. | $8.11 | $122.04 | 93% below | $293.7M | 562.4% | -71.6% |
| ABEO | ABEONA THERAPEUTICS INC. | $4.43 | $33.55 | 87% below | $293.0M | -150.8% | 23.2% |
| TTRX | Turn Therapeutics Inc. | $10.57 | — | — | $293.0M | -3124.1% | — |
| CMMB | Chemomab Therapeutics Ltd. | $1.26 | — | — | $287.9M | 316.5% | — |
| ELTP | ELITE PHARMACEUTICALS INC /NV/ | $0.25 | $1.00 | 75% below | $284.6M | 29.4% | 35.5% |
| ARCT | Arcturus Therapeutics Holdings Inc. | $10.34 | $11.63 | 11% below | $283.2M | 100.4% | 26.6% |
| RZLT | Rezolute, Inc. | $3.58 | — | — | $272.1M | 518.1% | — |
| RMTI | ROCKWELL MEDICAL, INC. | $7.43 | — | — | $267.3M | -163.2% | 3.0% |
| IMMX | Immix Biopharma, Inc. | $7.98 | — | — | $263.1M | 138.2% | — |
| SGMT | Sagimet Biosciences Inc. | $8.02 | — | — | $259.4M | -29.1% | — |
| PRLD | Prelude Therapeutics Inc | $3.26 | — | — | $250.9M | -81.8% | 73.4% |
| RCKT | ROCKET PHARMACEUTICALS, INC. | $2.18 | — | — | $242.2M | -76.0% | — |
| MREO | Mereo BioPharma Group plc | $0.30 | $6.33 | 95% below | $241.5M | 544.9% | -77.6% |
| LAB | STANDARD BIOTOOLS INC. | $0.63 | — | — | $240.0M | -107.8% | -2.2% |
| BCYC | BICYCLE THERAPEUTICS PLC | $3.46 | — | — | $239.7M | 126.2% | 56.1% |
| IRD | Opus Genetics, Inc. | $3.84 | $28.90 | 87% below | $238.9M | 196.3% | 29.6% |
| VNDA | Vanda Pharmaceuticals Inc. | $4.03 | $0.60 | 572% above | $237.5M | -4.9% | 4.5% |
| ASRT | Assertio Holdings, Inc. | — | — | — | — | -33.0% | -10.4% |
| NATR | NATURES SUNSHINE PRODUCTS INC | $12.64 | $35.21 | 64% below | $233.4M | 13.3% | 3.9% |
| GALT | GALECTIN THERAPEUTICS INC | $3.62 | — | — | $231.3M | -132.7% | — |
| NWBO | NORTHWEST BIOTHERAPEUTICS INC | $0.16 | — | — | $228.0M | 948.7% | 9.2% |
| SIGA | SIGA TECHNOLOGIES INC | $3.17 | — | — | $227.8M | -17.2% | 22.7% |
| ASMB | ASSEMBLY BIOSCIENCES, INC. | $20.09 | — | — | $225.2M | -131.7% | 29.7% |
| LFCR | LIFECORE BIOMEDICAL, INC. \DE\ | $6.38 | — | — | $222.1M | -5.8% | -13.5% |
| URGN | UroGen Pharma Ltd. | $34.56 | — | — | — | -167.7% | 22.6% |
| TBPH | Theravance Biopharma, Inc. | — | — | — | — | -86.7% | 9.2% |
| MGNX | MACROGENICS INC | $3.25 | — | — | $205.3M | 134.3% | 5.6% |
| GLSI | Greenwich LifeSciences, Inc. | $14.55 | — | — | $196.9M | -254.7% | — |
| CTNM | Contineum Therapeutics, Inc. | $7.08 | — | — | $196.1M | -53.3% | — |
| VERU | VERU INC. | $2.30 | $0.14 | 1543% above | $195.4M | -166.6% | -3.3% |
| ALT | Altimmune, Inc. | $2.20 | — | — | $193.8M | -116.6% | -38.5% |
| SCYX | SCYNEXIS INC | $3.67 | $46.17 | 92% below | $183.3M | 676.8% | 62.8% |
| TRDA | Entrada Therapeutics, Inc. | $4.37 | — | — | $180.8M | -5.6% | -55.6% |
| WHWK | Whitehawk Therapeutics, Inc. | $2.89 | $5.42 | 47% below | $178.9M | 256.7% | -13.8% |
| ADCT | ADC Therapeutics SA | $1.40 | — | — | $177.9M | -1.4% | 2.8% |
| ELDN | Eledon Pharmaceuticals, Inc. | $2.13 | $64.38 | 97% below | $174.3M | -390.7% | -76.0% |
| BIOA | BioAge Labs, Inc. | $4.84 | — | — | $173.9M | -60.0% | — |
| ORMP | ORAMED PHARMACEUTICALS INC. | $4.07 | $49.82 | 92% below | $172.6M | -37.2% | 13.5% |
| AKBA | Akebia Therapeutics, Inc. | $0.67 | — | — | $172.3M | -34.9% | 75.0% |
| RNAC | Cartesian Therapeutics, Inc. | $6.27 | — | — | $162.9M | 26.7% | -28.4% |
| CATX | Perspective Therapeutics, Inc. | $2.17 | $30.99 | 93% below | $160.2M | -65.1% | -17.1% |
| ETON | Eton Pharmaceuticals, Inc. | $50.31 | — | — | — | -296.4% | 109.0% |
| IMRX | Immuneering Corp | $3.59 | $128.68 | 97% below | $158.0M | -137.9% | -63.0% |
| SION | Sionna Therapeutics, Inc. | $3.89 | — | — | $155.5M | -123.0% | — |
| ZNTL | Zentalis Pharmaceuticals, Inc. | $2.13 | — | — | $153.1M | -15.8% | — |
| OVID | Ovid Therapeutics Inc. | $2.15 | — | — | $151.7M | -233.6% | -10.5% |
| AVTX | Avalo Therapeutics, Inc. | $11.27 | — | — | $151.1M | -16857.2% | -28.1% |
| UPB | Upstream Bio, Inc. | $2.76 | — | — | $148.6M | -34.0% | 9.5% |
| LYEL | Lyell Immunopharma, Inc. | $8.12 | $945.51 | 99% below | $138.8M | -14.4% | -38.4% |
| NKTX | Nkarta, Inc. | $1.80 | — | — | $133.2M | -25.2% | — |
| ORGO | Organogenesis Holdings Inc. | $1.00 | $0.77 | 30% above | $130.2M | -7.2% | 16.9% |
| RLMD | RELMADA THERAPEUTICS, INC. | $3.10 | — | — | $122.4M | 417.9% | — |
| DERM | Journey Medical Corp | $4.97 | $9.16 | 46% below | $121.6M | -343.9% | 6.6% |
| LRMR | Larimar Therapeutics, Inc. | $1.99 | — | — | $121.6M | -127.9% | — |
| CURX | Curanex Pharmaceuticals Inc | $4.62 | — | — | $117.8M | -65.6% | — |
| FHTX | Foghorn Therapeutics Inc. | $1.85 | — | — | $116.5M | -84.9% | 135.1% |
| LNAI | Lunai Bioworks Inc. | $0.68 | — | — | $112.3M | 11.1% | — |
| PEPG | PepGen Inc. | $2.60 | — | — | $109.8M | -158.0% | — |
| CPIX | CUMBERLAND PHARMACEUTICALS INC | $7.18 | — | — | $106.7M | -23.9% | 3.6% |
| PYXS | Pyxis Oncology, Inc. | $1.68 | $21.91 | 92% below | $104.4M | -5385.1% | -14.2% |
| ANTX | AN2 Therapeutics, Inc. | $3.38 | — | — | $102.1M | -57.5% | — |
| JUNS | JUPITER NEUROSCIENCES, INC. | $2.90 | — | — | $100.6M | 87.3% | — |
| IXHL | Incannex Healthcare Inc. | $2.82 | — | — | $97.2M | 623.8% | 616.7% |
| CAMP | Camp4 Therapeutics Corp | $3.17 | — | — | $96.3M | 98.2% | 216.1% |
| QTTB | Q32 Bio Inc. | $7.52 | $80.38 | 91% below | $92.6M | 254.8% | 39.1% |
| RLYB | Rallybio Corp | $16.28 | — | — | $91.6M | -3483.3% | 43.0% |
| GNLX | GENELUX Corp | $2.42 | $128.77 | 98% below | $90.0M | -40.8% | -91.0% |
| HOOK | HOOKIPA Pharma Inc. | — | — | — | — | 56.5% | 33.9% |
| BBOT | BridgeBio Oncology Therapeutics, Inc. | $2.82 | — | — | $87.8M | -1884.5% | — |
| PLYX | Polaryx Therapeutics, Inc. | $1.88 | — | — | $85.4M | -420.5% | — |
| IBO | IMPACT BIOMEDICAL INC. | $2.68 | $6.27 | 57% below | $83.5M | -42.4% | -13.8% |
| MANE | Veradermics, Inc | $108.82 | — | — | $81.1M | 42.8% | — |
| KRRO | Korro Bio, Inc. | $8.49 | $387.83 | 98% below | $79.8M | -54.9% | -22.3% |
| LFVN | Lifevantage Corp | $6.00 | $14.48 | 59% below | $77.9M | 49.1% | 1.1% |
| ZOMDF | Zomedica Corp. | $0.08 | — | — | $77.5M | -141.8% | 66.8% |
| AARD | Aardvark Therapeutics, Inc. | $3.78 | — | — | $74.2M | 121.3% | — |
| XLO | Xilio Therapeutics, Inc. | $8.55 | — | — | $71.5M | 993.4% | 589.9% |
| COYA | Coya Therapeutics, Inc. | $4.25 | — | — | $71.1M | 35.0% | 15.1% |
| MNOV | MEDICINOVA INC | $1.42 | $16.28 | 91% below | $69.7M | -72.0% | -43.6% |
| EQ | Equillium, Inc. | $1.19 | — | — | $68.2M | 3750.3% | 61.5% |
| MPLT | MapLight Therapeutics, Inc. | $7.70 | — | — | $66.8M | -67.5% | — |
| SPRO | Spero Therapeutics, Inc. | $1.10 | $4.98 | 78% below | $64.9M | -56.2% | 49.6% |
| PMVP | PMV Pharmaceuticals, Inc. | $1.21 | — | — | $63.6M | -23.5% | — |
| ACRV | Acrivon Therapeutics, Inc. | $1.64 | — | — | $63.2M | -84.2% | — |
| CRBP | Corbus Pharmaceuticals Holdings, Inc. | $4.52 | $102.72 | 96% below | $60.2M | 221.7% | -14.3% |
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