Upstream Bio, Inc. (UPB) intrinsic value & 10-year financials

Upstream Bio, Inc. (UPB) has no Graham intrinsic value right now because the formula needs positive earnings. Over the last 4 fiscal years revenue grew 9.5% a year to $2.9M, with an average return on invested capital of -34.0%.

Graham intrinsic value
—
Share price (Oct 17, 2026)
$2.76
Market cap
$148.6M
Revenue (FY2025)
$2.9M
Revenue growth (4-yr CAGR)
9.5%
ROIC (10-yr avg)
-34.0%
Free cash flow (FY2025)
-$133.4M

UPB 10-year financial history

Fiscal year Revenue Net income EPS (diluted) Free cash flow Operating margin ROIC
FY2025 $2.9M -$143.4M -$2.66 -$133.4M -5618.8% -83.6%
FY2024 $2.4M -$62.8M -$1.40 -$59.7M -3281.2% -53.6%
FY2023 $2.4M -$20.5M -$3.24 -$38.1M -1685.5% 35.0%
FY2022 — — — — — —

Source: annual 10-K filings on SEC EDGAR. Figures in USD.

Executive summary

Upstream Bio, Inc. revenue growth over the past decade is N/A; insufficient history prevents a reliable 10-year CAGR calculation.

Upstream Bio, Inc. has historically struggled to out-earn its cost of capital, averaging just -34.1% ROIC.

Upstream Bio, Inc. capital allocation metrics are N/A for the decade; share count and net debt history are incomplete.

Benjamin Graham lens

Under Benjamin Graham's formula using SEC EDGAR fundamentals, Upstream Bio, Inc. is modeled at 8.0% normalized earnings growth with a 5.1% bond-yield adjustment. The resulting Graham intrinsic value estimate is $-56.23 per share.

UPB stock: frequently asked questions

What is the intrinsic value of Upstream Bio, Inc. (UPB) stock?

Graham's formula only works with positive earnings. Upstream Bio, Inc. reported diluted EPS of -$2.66 in fiscal 2025, so no Graham value is shown. The 10-year table shows revenue and cash-flow trends instead.

Does Upstream Bio, Inc. generate free cash flow?

Upstream Bio, Inc. generated -$133.4M of free cash flow (operating cash flow minus capital expenditures) in fiscal 2025. Free cash flow was positive in 0 of the last 3 reported years.

What is UPB's return on invested capital?

Average ROIC over the last 4 fiscal years was -34.0%, and average return on equity was -17.9%. Sustained ROIC above about 15% usually points to a durable competitive advantage.

Where does this UPB data come from?

From Upstream Bio, Inc.'s annual 10-K filings on SEC EDGAR, most recently filed May 13, 2026. Prices are end-of-day snapshots; valuations are formula outputs, not investment advice.

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