Septerna, Inc. (SEPN) intrinsic value & 10-year financials

Septerna, Inc. (SEPN) has a Graham intrinsic value of $9.63 per share. At $36.35 on Oct 17, 2026, the stock trades 277% above that value. Over the last 4 fiscal years revenue grew 1644.5% a year to $46.0M, with an average return on invested capital of -68.5%.

Graham intrinsic value
$9.63
Share price (Oct 17, 2026)
$36.35
Price vs Graham value
277% above
Market cap
$1.6B
Revenue (FY2025)
$46.0M
Revenue growth (4-yr CAGR)
1644.5%
ROIC (10-yr avg)
-68.5%
Free cash flow (FY2025)
$109.7M

SEPN 10-year financial history

Fiscal year Revenue Net income EPS (diluted) Free cash flow Operating margin ROIC
FY2025 $46.0M -$48.9M -$1.10 $109.7M -148.6% -28.0%
FY2024 $1.1M -$71.8M -$7.26 -$69.6M -7518.4% -176.1%
FY2023 $151.0K $4.2M $0.29 -$41.6M 1374.2% -1.6%
FY2022 — — — — — —

Source: annual 10-K filings on SEC EDGAR. Figures in USD.

Executive summary

Septerna, Inc. revenue growth over the past decade is N/A; insufficient history prevents a reliable 10-year CAGR calculation.

Septerna, Inc. has historically struggled to out-earn its cost of capital, averaging just -10.4% ROIC.

Septerna, Inc. capital allocation metrics are N/A for the decade; share count and net debt history are incomplete.

Benjamin Graham lens

Under Benjamin Graham's formula using SEC EDGAR fundamentals, Septerna, Inc. is modeled at 15.0% normalized earnings growth with a 5.1% bond-yield adjustment. The resulting Graham intrinsic value estimate is $9.63 per share.

SEPN stock: frequently asked questions

What is the intrinsic value of Septerna, Inc. (SEPN) stock?

Using Benjamin Graham's revised formula, V = EPS × (8.5 + 2g) × 4.4 / Y, with reported diluted earnings per share, a 15.0% normalized growth rate (capped at 15%) and a 5.1% AAA corporate bond yield, SEPN's intrinsic value is about $9.63 per share.

Is SEPN stock undervalued?

At $36.35 (close on Oct 17, 2026), SEPN trades 277% above its Graham value of $9.63. On Graham's terms the shares look fully priced. A formula is a starting point for research, not a recommendation.

Does Septerna, Inc. generate free cash flow?

Septerna, Inc. generated $109.7M of free cash flow (operating cash flow minus capital expenditures) in fiscal 2025. Free cash flow was positive in 1 of the last 3 reported years.

What is SEPN's return on invested capital?

Average ROIC over the last 4 fiscal years was -68.5%, and average return on equity was -20.0%. Sustained ROIC above about 15% usually points to a durable competitive advantage.

Where does this SEPN data come from?

From Septerna, Inc.'s annual 10-K filings on SEC EDGAR, most recently filed Aug 10, 2026. Prices are end-of-day snapshots; valuations are formula outputs, not investment advice.

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