Spero Therapeutics, Inc. (SPRO) intrinsic value & 10-year financials

Spero Therapeutics, Inc. (SPRO) has a Graham intrinsic value of $4.98 per share. At $1.10 on Oct 17, 2026, the stock trades 78% below that value. Over the last 10 fiscal years revenue grew 49.6% a year to $12.6M, with an average return on invested capital of -56.2%.

Graham intrinsic value
$4.98
Share price (Oct 17, 2026)
$1.10
Price vs Graham value
78% below
Market cap
$64.9M
Revenue (FY2025)
$12.6M
Revenue growth (10-yr CAGR)
49.6%
ROIC (10-yr avg)
-56.2%
Free cash flow (FY2025)
—

SPRO 10-year financial history

Fiscal year Revenue Net income EPS (diluted) Free cash flow Operating margin ROIC
FY2025 $12.6M $8.6M $0.15 — 50.2% 79.2%
FY2024 $371.0K -$68.6M -$1.27 — -19773.9% -486.3%
FY2023 $933.0K $22.8M $0.43 — 2302.4% 625.1%
FY2022 $48.6M -$46.4M -$1.23 — -86.9% 181.3%
FY2021 $3.1M -$89.8M -$2.91 — -2865.5% -497.0%
FY2020 $258.0K -$78.3M — -$86.0M -30664.0% -153.3%
FY2019 $4.7M -$60.9M — -$50.3M -1333.1% -127.8%
FY2018 $4.0M -$41.7M — -$42.1M -1079.3% -42.8%
FY2017 $2.0M -$38.7M — -$39.1M -2108.6% -213.1%
FY2016 $335.0K -$25.5M — -$29.8M -9916.7% 73.1%

Source: annual 10-K filings on SEC EDGAR. Figures in USD.

Executive summary

Spero Therapeutics, Inc. is a consistent compounder, expanding top-line revenue at 49.6% annually over the past decade.

Spero Therapeutics, Inc. has historically struggled to out-earn its cost of capital, averaging just -2.4% ROIC.

Spero Therapeutics, Inc. capital allocation metrics are N/A for the decade; share count and net debt history are incomplete.

Benjamin Graham lens

Under Benjamin Graham's formula using SEC EDGAR fundamentals, Spero Therapeutics, Inc. is modeled at 15.0% normalized earnings growth with a 5.1% bond-yield adjustment. The resulting Graham intrinsic value estimate is $4.98 per share.

SPRO stock: frequently asked questions

What is the intrinsic value of Spero Therapeutics, Inc. (SPRO) stock?

Using Benjamin Graham's revised formula, V = EPS × (8.5 + 2g) × 4.4 / Y, with reported diluted earnings per share, a 15.0% normalized growth rate (capped at 15%) and a 5.1% AAA corporate bond yield, SPRO's intrinsic value is about $4.98 per share.

Is SPRO stock undervalued?

At $1.10 (close on Oct 17, 2026), SPRO trades 78% below its Graham value of $4.98. On Graham's terms that leaves a margin of safety. A formula is a starting point for research, not a recommendation.

How fast has Spero Therapeutics, Inc. grown?

Revenue went from $335.0K in fiscal 2016 to $12.6M in fiscal 2025, a compound annual growth rate of 49.6%. Net income was $8.6M in fiscal 2025.

What is SPRO's return on invested capital?

Average ROIC over the last 10 fiscal years was -56.2%, and average return on equity was -51.0%. Sustained ROIC above about 15% usually points to a durable competitive advantage.

Where does this SPRO data come from?

From Spero Therapeutics, Inc.'s annual 10-K filings on SEC EDGAR, most recently filed May 13, 2026. Prices are end-of-day snapshots; valuations are formula outputs, not investment advice.

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